Peptide Evidence Tiers

Honest, evidence-tiered breakdowns. Tap any peptide for the full research card.

How to read the evidence tiers

Tier AProven & approved. FDA-approved or backed by human RCTs / meta-analyses.

Tier BSolid human data. Multiple human trials; not yet fully approved for this use.

Tier CEmerging. Limited human data (small/pilot); strong preclinical support.

Tier DExperimental. Animal/lab data only — no meaningful human evidence yet.

Each peptide is scored 0–5 ● on Safety, Human studies, Animal studies, and FDA status — see the dots on each card, and the full bars once expanded.

GLP-1 & Metabolic

Weight, Blood Sugar & Body Composition

The strongest-evidence category on this page — FDA-approved incretin drugs with large human RCTs and meta-analyses.

Growth Hormone (GH) Peptides

GH Secretagogues & GHRH Analogues

These raise your own growth hormone / IGF-1. Evidence quality varies widely — MK-677 and Sermorelin have the most human data; the rest are early. Only Tesamorelin is FDA-approved (for a specific use), and Sermorelin was approved (withdrawn 2008 for commercial, not safety, reasons). All non-approved GH peptides are WADA-banned and sold “research use only.”

Mitochondrial Health Peptides

Cellular Energy & Longevity

The most experimental category. Compelling biology, but for healthy adults these are largely preclinical — SS-31 is the exception (FDA-approved for Barth syndrome only; its largest general-myopathy trial failed).

Tissue Repair & Recovery

Injury, Tendon & Gut Healing

All of these are investigational — popular for recovery, but human evidence is early. Not FDA-approved; most are WADA-banned and sold “research use only.”

Neuro & Longevity Peptides

Cognition, Neuroprotection & Aging

The most speculative category for U.S. users. Some (Semax) are approved in Russia — not the FDA — and most Western human evidence is thin to nonexistent. Not FDA-approved; sold “research use only.”