Evidence-Based · CSCS Curated

The Supplement Guide

No hype, no sponsorships. Honest recommendations by category — backed by research and 18 years of real-world training experience.

✦ Curated by Cameron Scharnick, B.S. Exercise Science · NSCA-CSCS
Disclosure: Some links on this page are Amazon affiliate links. If you purchase through them, we earn a small commission at no extra cost to you. This does not influence our recommendations — we only list what we'd actually use or recommend to clients.
🧱 Foundational 💪 Muscle Building 🔥 Fat Loss ⚡ Recovery 😴 Sleep & Stress ⚙️ Hormonal Support 🧬 Longevity 🔬 Peptides
🧱
Foundational Stack
Start here. These fill the gaps that diet alone rarely covers.
★ Top Pick
PhytoMulti Multivitamin
Metagenics
Strong
Clinical-grade multivitamin with phytonutrient complex. Higher bioavailability than standard drugstore multis. Used in integrative and functional medicine practices.
Dose: 2 tablets daily with food
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Vitamin D3 + K2
Thorne Research
Strong
The combination form matters — K2 directs calcium into bone rather than arteries. Most people in the US are deficient in D3. Critical for testosterone, immune function, and bone density.
Dose: 2,000–5,000 IU D3 + 100–200mcg K2 daily
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Omega-3 Fish Oil
Nordic Naturals Ultimate Omega
Strong
Anti-inflammatory, cardiovascular protection, and supports muscle protein synthesis. Look for 2–3g combined EPA+DHA daily. Nordic Naturals is third-party tested for purity and oxidation.
Dose: 2–3g EPA+DHA per day with meals
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Magnesium Glycinate
Doctor's Best
Strong
Over 300 enzymatic reactions depend on magnesium. The glycinate form is the most bioavailable and least likely to cause GI issues. Supports sleep quality, muscle relaxation, and stress response.
Dose: 200–400mg before bed
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💪
Muscle Building
The most evidence-backed compounds for strength and hypertrophy.
★ Best in Category
Creatine Monohydrate
Optimum Nutrition
Strong
The single most researched performance supplement that exists. Increases phosphocreatine stores, boosts ATP regeneration, and directly improves strength and power output. Works for everyone — regardless of training age.
Dose: 3–5g daily. No loading required.
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Gold Standard 100% Whey
Optimum Nutrition
Strong
Fast-digesting whey protein isolate as the primary source. 24g protein per scoop, low in fat and carbs. Leucine-rich to maximally trigger muscle protein synthesis. Benchmark product in the industry for quality and value.
Dose: 25–50g post-workout or as needed to hit daily protein target
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Beta-Alanine
NOW Sports
Good
Raises muscle carnosine — your intracellular pH buffer during high-intensity sets. Most effective for efforts lasting 1–4 minutes. Reduces muscular fatigue and improves conditioning output. Tingling (paresthesia) is normal and harmless.
Dose: 3.2–6.4g/day in divided doses to reduce tingling
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Citrulline Malate 2:1
Bulk Supplements
Good
Precursor to arginine — raises nitric oxide more effectively than arginine itself. Improves blood flow, pumps, and exercise capacity. Reduces post-workout muscle soreness. Pure powder, zero fillers.
Dose: 6–8g 30–45 min before training
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🔥
Fat Loss Support
Compounds that support body recomposition — not magic pills, but real tools.
★ Best in Category
Caffeine + L-Theanine Stack
NOW Foods
Strong
The most cost-effective pre-workout and fat loss stack available. Caffeine raises metabolic rate and lipolysis. L-Theanine smooths out jitteriness and sustains focus. The combination outperforms either compound alone.
Dose: 100–200mg caffeine + 200mg L-Theanine pre-workout
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L-Carnitine L-Tartrate
NOW Sports
Good
Shuttles fatty acids into the mitochondria for oxidation. Most effective when insulin is elevated — take with a carb-containing meal. Tartrate form has the best absorption and is supported by exercise performance research.
Dose: 2g with a carbohydrate-containing meal
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Green Tea Extract (EGCG)
NOW Foods
Good
EGCG inhibits the enzyme that breaks down norepinephrine, sustaining fat oxidation signals. Synergistic with caffeine. Also has significant antioxidant and cardiovascular protective properties.
Dose: 400–500mg EGCG daily with caffeine
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Berberine HCl
Thorne Research
Good
AMPK activator — mimics some effects of metformin on glucose metabolism. Improves insulin sensitivity and reduces post-meal blood sugar spikes. Strong evidence for metabolic health in people managing body composition or blood sugar. Physician oversight recommended at therapeutic doses.
Dose: 500mg 2–3x daily with meals
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Recovery & Inflammation
What happens between sessions is where adaptation lives.
★ Best in Category
Collagen Peptides + Vitamin C
Vital Proteins
Good
Connective tissue synthesis requires both collagen peptides and Vitamin C as the cofactor. Take 15–20g collagen + 50mg Vitamin C roughly 60 minutes before training for maximum tendon and ligament collagen synthesis stimulus.
Dose: 15–20g + 50mg Vitamin C, 45–60 min pre-workout
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Tart Cherry Extract
NOW Foods
Good
Reduces exercise-induced oxidative stress and inflammation. Multiple RCTs show reduced muscle soreness and faster strength recovery after eccentric training. Also supports sleep quality via natural melatonin precursors.
Dose: 480mg extract twice daily on training days
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Curcumin Phytosome
Thorne Meriva
Good
Standard curcumin has poor bioavailability. Meriva phytosome form improves absorption ~29x. Anti-inflammatory through NF-kB pathway inhibition. Useful for chronic inflammation management — use timing wisely as acute post-workout inflammation is part of adaptation.
Dose: 500–1000mg phytosome form on non-training days or at night
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Zinc Picolinate
Thorne Research
Strong
Zinc is critical for testosterone production, immune function, and protein synthesis. Picolinate form has superior absorption. Athletes and hard-training individuals deplete zinc through sweat — deficiency is more common than most people realize.
Dose: 15–30mg daily with food (not on empty stomach)
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😴
Sleep & Stress
Poor sleep undoes everything you build in the gym. Fix this first.
★ Best in Category
KSM-66 Ashwagandha
Jarrow Formulas
Strong
The most clinically studied ashwagandha extract. KSM-66 is full-spectrum root extract standardized to ≥5% withanolides. Reduces cortisol, improves VO2 max, and supports testosterone in stressed individuals. Multiple RCTs confirm the effect.
Dose: 600mg daily (split or single evening dose)
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L-Theanine 200mg
NOW Foods
Strong
Promotes alpha brain wave activity — a calm, focused state without sedation. Reduces cortisol response to stress. Pairs perfectly with caffeine during the day and with magnesium glycinate at night for sleep quality.
Dose: 200mg morning (with caffeine) and/or 200mg before bed
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Glycine
NOW Foods
Good
Inhibitory neurotransmitter with sleep-promoting effects. Studies show 3g before bed improves sleep quality, reduces daytime sleepiness, and enhances next-day cognitive performance. Also precursor to collagen and glutathione.
Dose: 3g before bed
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Apigenin
Thorne Research
Moderate
Chamomile-derived flavonoid that binds GABA-A receptors (same pathway as benzodiazepines — without the dependency risk). Popular in sleep stack protocols. Popularized by Dr. Andrew Huberman; evidence is promising but not yet as deep as ashwagandha or glycine.
Dose: 50mg 30–60 min before bed
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⚙️
Hormonal Support
Supports healthy testosterone, estrogen balance, and metabolic function. Not a replacement for medical evaluation.
★ Best in Category
Tongkat Ali (Longjack) 400mg
Nutricost
Good
Eurycomanone content drives free testosterone by reducing SHBG. Multiple RCTs in stressed, aging, or low-T individuals show significant improvements in testosterone levels, mood, and body composition. Stack with zinc and magnesium for amplified effect.
Dose: 400mg standardized extract daily (200:1 or higher)
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DIM (Diindolylmethane)
NOW Foods
Moderate
Supports healthy estrogen metabolism by shifting estradiol toward the favorable 2-OH pathway and away from the 16-OH and 4-OH pathways. Relevant for men on TRT or optimization protocols and for women managing estrogen dominance symptoms.
Dose: 200–400mg daily with food
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Boron Glycinate 6mg
NOW Foods
Moderate
Trace mineral that reduces SHBG — the protein that binds and inactivates testosterone. Studies show 6mg/day boron glycinate significantly increases free testosterone and reduces estradiol within one week. Extremely underrated and underused.
Dose: 6mg daily with food
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DHEA 25mg
Natrol
Moderate
Precursor hormone to testosterone and estrogen. DHEA declines significantly after age 30. Low-dose supplementation (25mg) is appropriate for adults 40+ without TRT. Get baseline DHEA-S levels before supplementing. Physician oversight recommended.
Dose: 25–50mg daily. Lab-test first.
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🧬
Longevity & Cellular Health
Advanced compounds targeting aging pathways. Emerging research — promising, but evolving.
★ Best in Category
NMN Pro 1000mg
ProHealth Longevity
Emerging
NMN is a direct precursor to NAD+ — the coenzyme that drives energy metabolism and DNA repair. NAD+ declines ~50% by age 50. Human trials show improved metabolic markers, muscle function, and sleep quality. ProHealth uses pharmaceutical-grade NMN with stability testing.
Dose: 500–1000mg daily in the morning
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CoQ10 Ubiquinol 200mg
Qunol
Good
Ubiquinol is the active reduced form of CoQ10 — significantly better absorbed than standard ubiquinone, especially over age 40 when conversion efficiency drops. Critical for mitochondrial ATP production. Essential for anyone on a statin (statins deplete CoQ10).
Dose: 100–200mg ubiquinol daily with fat-containing meal
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Resveratrol + Quercetin
NOW Foods
Emerging
Resveratrol activates SIRT1 (sirtuins) and works synergistically with NMN to support NAD+ pathways. Quercetin is a senolytic — meaning it clears senescent ("zombie") cells that accumulate with age and drive inflammation. Stack both for maximum longevity signal.
Dose: 500mg resveratrol + 500mg quercetin daily with fat
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Spermidine
Primeadine
Emerging
Triggers autophagy — the cellular "self-cleaning" process that clears damaged proteins and organelles. Animal data is strong; human data is catching up fast. Naturally found in wheat germ and fermented foods. One of the most exciting emerging longevity compounds available OTC.
Dose: 1–2mg/day. Cycle: 5 on / 2 off.
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🔬 Peptide Protocols

Peptides represent the next tier of performance and longevity optimization — beyond what OTC supplements can offer. BPC-157, TB-500, CJC-1295, Ipamorelin, Epithalon, MOTS-c, and more. These require physician oversight and are only available through medical channels.

Cam works with The Body Building med spa in Clovis, CA — offering physician-supervised peptide protocols alongside hyperbaric, cryotherapy, and hormone management.

Browse the Peptide Library → Visit TBB →
Evidence Rating Guide
Strong — Multiple RCTs, consistent effect Good — Several studies, generally consistent Moderate — Some evidence, mechanism plausible Emerging — Early data, promising but limited human trials